What is Tyrosine
Chemical Name: (S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Molecular Weight: 181.2
Nitrogen Content: 7.73%
Tyrosine (13, 14)
- L-Tyrosine is a non-essential (or semi-essential), neutral, genetically coded amino acid. It is very little soluble in water
- Tyrosine synthesized in the body from phenylalanine
- As a building block for several important brain chemicals, tyrosine is needed to make epinephrine, norepinephrine, serotonin, and dopamine, all of which work to regulate mood
- Tyrosine also aids in the production of melanin (pigment responsible for hair and skin color) and in the function of organs in the body responsible for making and regulating hormones, including the adrenal, thryroid, and pituitary glands
- Tyrosine is also involved in the synthesis of enkephalins, substances that have pain-relieving effects in the body
- As tyrosine binds unstable molecules (called free radicals) that can potentially cause damage to the cells and tissues, it is considered as a mild antioxidant
- Thus, tyrosine may be useful for people who have been exposed to harmful chemicals (such as from smoking) and radiation
Tyrosine and Stress (222)
- Tyrosine acts as an adaptogen, helping the body adapt to and cope with the effects of physical or psychological stress by minimizing the symptoms brought on by stress
- This is primarily due to the fact that tyrosine is a building block for norepinephine and epinephrine, the body’s two main stress-related hormones
- Taken ahead of time, tyrosine allows some people to avoid typical bodily reactions and feelings from stressful situations like surgery, emotional upset, and sleep deprivation.
Tyrosine and Anxiety-related Hypertension (197, 198)
Tyrosine and Depression (23, 188, 189, 223, 224)
- Tyrosine levels are occasionally low in depressed patients
- A number of studies conducted in the 1970s showed encouraging results regarding the use of tyrosine to ease symptoms of depression, especially when used together with another supplement known as 5-hydroxytryptophan (5-HTP)
- In one study from 1990, however, tyrosine failed to demonstrate any anti-depressant activity
- More studies are needed in order to draw firm conclusions about the use of tyrosine to help treat mild to moderate depression
Tyrosine and Parkinson’s (225)
- In the mid 1980s some researchers speculated that tyrosine may be useful for treating Parkinson’s
- As Tyrosine can increase dopamine levels. (Diminished dopamine levels cause the symptoms of Parkinson’s disease)
- However, this has never been proven and there is a question about how well oral tyrosine can get into the brain
- Some medications for Parkinson’s currently under investigation that incorporate tyrosine along with other chemicals
Deficiencies in tyrosine (226)
Deficiencies in tyrosine would cause the following stmptoms:
- Low blood pressure
- Low body temperature
- An under active thyroid
Tyrosine and Food (13)
Tyrosine can be found in:
- soy products
- Cottage cheese
- Lima beans
- Pumpkin seeds
- Sesame seeds
Tyrosine and Cocaine addition
- Cocaine addiction causes a deficiency of L-dopamine and causes both catecholamine and serotonin neurotransmitter imbalances
- Administering both L-tyrosine and L-tryptophan can help increase these neurotransmitters
- This regimen has been used in chemical dependency units, along with conventional therapies
Best used with Tyrosine (13)
If taking a tyrosine supplement it is best to take it at bedtime, or with a high carbohydrate meal to prevent competition of absorption with other amino acids. Folic acid, copper and vitamin B6 is a good combination to have with this nutrient to maximize absorption and effectiveness.
Precaution of Tyrosine (61)
- Total amount of tyrosine taken in one day should never exceed 12,000 mg
- Those who suffer from migraine headaches should avoid tyrosine, as it can trigger migraine headaches and gastrointestinal upset
- Tyrosine should not be taken at the same time as levodopa, a medication used to treat Parkinson’s disease because levodopa may interfere with the absorption of Tyrosine
- 13) Balch, James, MD, and Phyllis Balch, CNC, Prescription for Nutritional Healing, Avery Pub., 1997.
- 14) Di Pasquale, M, Amino Acids and Proteins for the Athlete, the Anabolic Edge, 1997.
- 23) Buist, R. Therapeutic predictability of tryptophan and tyrosine in treatment of depression, International Clinical Nutrition Review, 3(2):1-3
- 188) Gibson, C. Tyrosine for treatment of depression, Advanced Biological Psychiatry, 10: 148-59
- 189) Gelenberg, A. Tyrosine for the treatment of depression, American Journal of Psychiatry, 147: 622
- 197) Philpott, W. Selective amino acid deficiencies, Information pamphlet isssued by Klaire Laboratories, California
- 198) Morgan B. and R. Brian Food, Michael Joseph, London
- 222) Fugh-Berman A, Cott JM. Dietary supplements and natural products as psychotherapeutic agents. Psychosom Med . 1999;61:712-728.
- 223) Gelenberg AJ, Wojcik JD, Falk WE, et al. Tyrosine for depression: a double-blind trial . J Affect Disord. 1990;19:125-132.
- 224) Meyers S. Use of neurotransmitter precursors for treatment of depression. Altern Med Rev . 2000;5(1):64-71.
- 225) Growdon JH, Melamed E, Logue M, et al. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson’s disease. Life Sci . 1982;30:827-832.
- 226) Bartholome K. Deficiency of tyrosine hydroxylase or tryptophan hydroxylase: a possible cause of two hypothetical metabolic diseases. Acta Paediatr Scand. 1983 Nov;72(6):921-2.
- 61) Peter J. Garlick. The Nature of Human Hazards Associated with Excessive Intake of Amino Acids. J. Nutr. 2004 134: 1633-1639.
- 266) Awad AG. Diet and drug interactions in the treatment of mental illness – a review. Can J Psychiatry. 1984;29:609-613.
- 267) Camacho F, Mazuecos J. Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience. Arch Dermatol. 1999;135:216-217
- 268) Chakraborty DP, Roy S, Chakroborty AK. Vitiligo, psoralen, and meanogenesis: some observations and understanding. Pigment Cell Res. 1996;9(3):107-116.
- 269) Chiaroni P, Azorin JM, Bovier P, et al. A multivariate analysis of red blood cell membrane transports and plasma levels of L-tyrosine and L-tryptophan in depressed patients before treatment and after clinical improvement. Neuropsychobiology. 1990;23(1):1-7.
- 270) Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-323.
- 271) Fernstrom JD. Can nutrient supplements modify brain function? Am J Clin Nutr. 2000;71(6 Suppl):1669S-1675S.
- 222) Fugh-Berman A, Cott JM. Dietary supplements and natural products as psychotherapeutic agents. Psychosom Med. 1999;61:712-728.
- 272) Gelenberg AJ, Wojcik JD, Falk WE, et al. Tyrosine for depression: a double-blind trial. J Affect Disord. 1990;19:125-132.
- 225)Growdon JH, Melamed E, Logue M, et al. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson’s disease. Life Sci. 1982;30:827-832,
- 287)Hull KM, Maher TJ. L-Tyrosine potentiates the anorexia induced by mixed-acting sympathomimetic drugs in hyperphagic rats. J Pharmacol Exp Ther. 1990;255(2):403-409.
- 273) Hull KM, Tolland DE, Maher TJ. L-tyrosine potentiation of opioid-induced analgesia utilizing the hot-plate test. J Pharmacol Exp Ther. 1994;269(3):1190-1195.
- 274) Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev. 1999;4940;249-265.
- 275) Kirschmann GJ and Kirschmann JD. Nutrition Almanac, 4th ed. New York, NY: McGraw-Hill;1966:304.
- 276) Koch R. Tyrosine supplementation for phenylketonuria treatment. Am J Clin Nutr. 1996;64(6):974-975.
- 277) Menkes DB, Coates DC, Fawcett JP. Acute tryptophan depletion aggravates premenstrual syndrome. J Affect Disord. 1994;3291):37-44.
- 224) Meyers S. Use of neurotransmitter precursors for treatment of depression. Altern Med Rev. 2000;5(1):64-71.
- 278) Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness.
Aviat Space Environ Med. 1995;66(4):313-319.
- 279) Parry BL. The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications. CNS Drugs. 2001;15(4):277-285.
- 280) Pizzorno JE and Murray MT. Textbook of Natural Medicine, Vol 2. New York, NY: Churchill Livingstone; 1999:1049-1059.
- 281) Poustie VJ, Rutherford P. Tyrosine supplementation for phenylketonuria. Cochrane Database Syst Rev. 2000;(2):CD001507.
- 282) Riederer P. L-Dopa competes with tyrosine and tryptophan for human brain uptake. Nutr Metab. 1980;24(6):417-423.
- 283) Smith ML, Hanley WB, Clarke JT, et al. Randomised controlled trial of tyrosine supplementation on neuropsychological performance in phenylketonuria. Arch Dis Child. 1998;78(2):116-121.
- 284) van Spronsen FJ, van Rijn M, Bekhof J, Koch R, Smit PG. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr. 2001;73(2):153-157.
- 286) Wagenmakers AJ. Amino acid supplements to improve athletic performance. Curr Opin Clin Nutr Metab Care. 1999;2(6):539-544.
- 286) Yehuda S. Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine. A new molecule. Pharmacol Biochem Behav. 2002;72(1-2):7-11.