Aspartic Acid

What is Aspartic Acid

Chemical Name: (2S)-2-aminobutanedioic acid

Molecular Weight: 133.1

Structrual Formula:

Nitrogen Content: 10.52%

Aspartic Acid (13, 14)

  • L-aspartic acid is one of the non-essential amino acids commonly occurring in the L-form
  • Existing mainly in the form of its amide, asparagine
  • Found in abundance in plant proteins, especially in sprouting seeds but can be manufactured in the body from oxaloacetic acid
  • Aspartic acid, as well as glutamic acid, is the only amino acid that has a negatively charged carboxylate group on the side chain
  • It is of paramount importance in the metabolism during construction of other amino acids and biochemicals in the citric acid cycle
  • Among the biochemicals that are synthesized from aspartic acid are asparagine, arginine, lysine, methionine, threonine, isoleucine, and several nucleotides
  • It is needed for stamina, brain and neural health
    assists the liver by removing excess ammonia and other toxins from the bloodstream
  • It is also very important in the functioning of RNA, DNA, as well as the production of immunoglobulin and antibody synthesis
  • It also performs an important role in the urea cycle and helping to transport minerals
  • Along with potassium or magnesium salt, aspartic acid is useful in physiological cellular function

Aspartic acid and resistance to fatigue (87)

  • Because aspartic acid increases stamina, it is an excellent supplement to battle fatigue and depression
  • Chronic fatigue has in fact been traced to low levels of aspartic acid, because that in turn can lead to lowered cellular energy
  • For these reasons, athletes in particular can benefit greatly from a supplement of aspartic acid

Aspartic acid and Expulsion of harmful ammonia (88)

  • Aspartic acid aids in the expulsion of ammonia from the body
  • When ammonia enters the circulatory system it acts as a toxin that can be harmful to the central nervous system
  • aspartic acid remove harmful ammonia by combining with other amino acids to form larger molecules that absorb toxins and remove them from the bloodstream
  • By disposing of ammonia, aspartic acid helps protect the central nervous system

Deficiency of aspartic acid (89)

  • fatigue
  • depression

Aspartic Acid and Food

  • Aspartic acid can be found in dairy, beef, poultry and sprouting seeds

Reference

  • 13) Balch, James, MD, and Phyllis Balch, CNC, Prescription for Nutritional Healing, Avery Pub., 1997.
  • 14) Di Pasquale, M, Amino Acids and Proteins for the Athlete, the Anabolic Edge, 1997.
  • 87) Marquezi ML, Roschel HA, dos Santa Costa A, Sawada LA, Lancha AH Jr. Effect of aspartate and asparagine supplementation on fatigue determinants in intense exercise. Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):65-75.
  • 88) Meijer AJ. Amino acids as regulators and components of nonproteinogenic pathways. J Nutr. 2003 Jun;133(6 Suppl 1):2057-2062.
  • 89) Peter J. Garlick. The Nature of Human Hazards Associated with Excessive Intake of Amino Acids. J. Nutr. 2004 134: 1633-1639.
  • 62) Munro HN, Crim MC, In Shila Me, Young VR (eds) “Modern Nutrition in Health and Disease” (7th ed). Philadelphia. Lea and Febiger, 1986. pp 1-37.
  • 90) “Concise Encyclopedia of Biochemistry” New York. Walter de Gruyter, 1983.
  • 91) Rodwell VW. In Martin Jr, DW et at (eds). “Harper’s Review of Biochemistry” (20th ed) Los Altos, CA. Lange, 1985. pp 293-318.
  • 92) White A. Handler P, Smith El, et al. “Principles of Biochemistry” (20th ed). New York. McGraw-Hill, 1978.
  • 93) Bradford HF, “Chemical Neurobiology: An Introduction to Neurochemistry.” New York: WH Freeman. 1986.
  • 94) Plaitakis A, Berl S. “J Neural Transmission.” 1983; Suppl 19: 65-74.
  • 95) Cooney DA, Capizzi RL, Handschumacher RE, “Cancer Research.” 1970; 30:929-935.
  • 96) Patten BM, Harati Y, Acosta L, et al. “Ann Neurol.” 1978; 3:305-309.
  • 97) Mindell, Earl. Vitamin Bible for the 21st Century, 2001.
  • 98) Cooper, Dr. Kenneth H. Advanced Nutritional Therapies, 1996.
  • 99) Kirschmann, John. Nutrition Almanac. New York: McGraw-Hill, 1984.
  • 100) Borton, Benjamin. Human Nutrition. New York: McGraw-Hill, 1978.
  • 101) Mindell, Earl. Vitamin Bible. New York: Rawson, Wade, 1980.
  • 102) Benowieez, Robert. Vitamins & You. New York: Berklett books, 1981.
  • 103) Gottlieb, William. The Complete Book of Vitamins. Emmaus, PA: Rodale Press, 1984.
  • 104) Tierra, Michael. The Way of Herbs. New York: Washington Square Press, 1983.