• MELATONIN is a hormone produced in the pineal gland, a small gland in the brain that helps regulate sleep and wake cycles. .

• The body has its own internal clock that helps regulate the natural cycle of sleeping and waking hours (or circadian rhythm) in part by controlling the production of MELATONIN. Normally, MELATONIN levels begin to rise in the mid or late evening, remain high for most of the night, and then decline in the early morning hours.

• Natural MELATONIN levels decline gradually with age. Some older adults produce very small amounts of MELATONIN or none at all.

Treatment of Seasonal Affective disorder (SAD) Helping Regulate Sleep for people who work evenings or nights Preventing or reducing problems with sleeping or confusion after Surgery Reducing chronic cluster headaches

11

Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder Ann Pharmacother. 2009 Dec 22